The role of interleukin-18 in the metabolic syndrome

The role of interleukin-18 in the metabolic syndrome

Blog Article

Abstract The metabolic syndrome is thought to be associated with a chronic low-grade inflammation, and a growing body of evidence suggests that interleukin-18 (IL-18) might be closely related to the metabolic syndrome and its consequences.Circulating levels of IL-18 have been reported to be elevated in subjects with the metabolic syndrome, Gear - Pants to be closely associated with the components of the syndrome, to predict cardiovascular events and mortality in populations with the metabolic syndrome and to precede the development of type 2 diabetes.IL-18 is found in the unstable atherosclerotic plaque, in adipose tissue and 8x10 Print in muscle tissue, and is subject to several regulatory steps including cleavage by caspase-1, inactivation by IL-18 binding protein and the influence of other cytokines in modulating its interaction with the IL-18 receptor.

The purpose of this review is to outline the role of IL-18 in the metabolic syndrome, with particular emphasis on cardiovascular risk and the potential effect of life style interventions.